Issue 37, 2011
From the journal:

Chemical Communications

Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit†‡

Christopher E. Martin,ab   Markus W. Weishauptab  and  Peter H. Seeberger*ab  

* Corresponding authors

a Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Mühlenberg 1, 14476 Potsdam, Germany
E-mail: peter.seeberger@mpikg.mpg.de

b Freie Universität Berlin, Institute for Chemistry and Biochemistry, Arnimallee 22, 14195 Berlin, Germany

Abstract

Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.

Graphical abstract: Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

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Article information

DOI
https://doi.org/10.1039/C1CC13614C
Article type
Communication
Submitted
17 jún 2011
Accepted
21 júl 2011
First published
18 aug 2011

Chem. Commun., 2011,47, 10260-10262

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Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

C. E. Martin, M. W. Weishaupt and P. H. Seeberger, Chem. Commun., 2011, 47, 10260 DOI: 10.1039/C1CC13614C

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