A membrane camouflaged copper single-atom nanozyme for combined mild photothermal and chemodynamic therapy

Chunmei Guo; Yi Zhou; Xiaolong Zhang; Jingyi Shi; Yuhao Zu; Lina Qi; Jianhang Zhao; Quli Fan; Ying Chen; Hui Zhou

doi:10.1039/D5CC04269K

A membrane camouflaged copper single-atom nanozyme for combined mild photothermal and chemodynamic therapy

Chunmei Guo,

^a Yi Zhou,^a Xiaolong Zhang,^a Jingyi Shi,^a Yuhao Zu,^a Lina Qi,^a Jianhang Zhao,^a Quli Fan,

^a Ying Chen

*^a and Hui Zhou

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Flexible Electronics (LoFE), Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China
E-mail: iamyingchen@njupt.edu.cn, iamhzhou@njupt.edu.cn

Abstract

A copper (Cu) single-atom nanozyme coated with 4T1 tumor cell membrane was constructed to enhance tumor targeting and biocompatibility. The platform combines chemodynamic therapy (CDT) and mild photothermal therapy (PTT) for improved antitumor efficacy and enables precise tumor detection via photoacoustic imaging (PAI).

This article is part of the themed collections: 2025 Emerging Investigators and Chemical Communications HOT articles 2025

Chemical Communications

A membrane camouflaged copper single-atom nanozyme for combined mild photothermal and chemodynamic therapy

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A membrane camouflaged copper single-atom nanozyme for combined mild photothermal and chemodynamic therapy

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