3D-Printed Biomimetic Scaffold Loaded with ADSCs and BMP-2 for Enhanced Rotator Cuff Repair

Abstract

Rotator cuff tear repair poses significant challenges due to the complex gradient interface structure. In the face of disease-related disruptions in the tendon-bone interface (TBI), the strategy of constructing a biomimetic scaffold is a promising avenue. A novel 3D-printed rotator cuff scaffold loaded adipose stem cells (ADSCs), bone morphogenetic protein-2 (BMP-2), and collagen type I (COL I). The efficiency of the slow-release BMP-2 design depended on the dopamine-hyaluronic acid (HAD) and BMP-2 reaction. The cumulative release of BMP-2 was 44.97% ± 5.45% at 4 weeks. The 3D-printed bilayer scaffold, incorporating COL I and BMP-2, effectively promoted the differentiation of ADSCs into osteogenic, tenogenic, and chondrogenic lineages in vitro. The combination of 3D-printed bioactive scaffolds and ADSCs demonstrated a superior repair effect on rotator cuff injuries in vivo. Therefore, these findings indicated that the 3D-printed biomimetic scaffold loaded with ADSCs and BMP-2 holds potential as a promising graft for TBI healing.

Supplementary files

Article information

Article type
Paper
Submitted
17 máj 2024
Accepted
23 okt 2024
First published
24 okt 2024

J. Mater. Chem. B, 2024, Accepted Manuscript

3D-Printed Biomimetic Scaffold Loaded with ADSCs and BMP-2 for Enhanced Rotator Cuff Repair

Z. Wu, J. Yang, H. Chong, X. Dai, H. Sun, J. Shi, M. Yuan, D. Liu, M. Dang, H. Yao and W. Fei, J. Mater. Chem. B, 2024, Accepted Manuscript , DOI: 10.1039/D4TB01073F

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