Issue 5, 2024

The first-row transition metal-catalysed enantioconvergent radical Suzuki–Miyaura C(sp3)–C coupling of racemic alkyl halides

Abstract

The enantioconvergent radical Suzuki–Miyaura cross-coupling of racemic alkyl halides represents a powerful approach for the construction of valuable C(sp3)–C bonds. In this regard, the earth-abundant first-row transition metal (Ni, Fe, Co, and Cu) catalyst possesses a good single-electron transfer ability and can easily convert racemic alkyl halides to the prochiral alkyl radicals, providing an ideal solution for enantioconvergence. The utilization of chiral ligands would further facilitate the realization of enantioselective control over the prochiral alkyl radicals. This Perspective will discuss the advances and anticipate further development in this burgeoning field.

Graphical abstract: The first-row transition metal-catalysed enantioconvergent radical Suzuki–Miyaura C(sp3)–C coupling of racemic alkyl halides

Article information

Article type
Perspective
Submitted
28 júl 2023
Accepted
17 jan 2024
First published
18 jan 2024

Green Chem., 2024,26, 2525-2533

The first-row transition metal-catalysed enantioconvergent radical Suzuki–Miyaura C(sp3)–C coupling of racemic alkyl halides

L. Liu, C. Yang, Z. Li, Q. Gu and X. Liu, Green Chem., 2024, 26, 2525 DOI: 10.1039/D3GC02793G

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