Issue 18, 2023
From the journal:

Green Chemistry

Solvent-free and catalyst-free direct alkylation of alkenes†‡

Meng-Yao Li, ORCID logo §a   Jiatong Li,§a   Ao Gu,a   Xiao-Mei Nong,a   Shuyang Zhai,a   Zhu-Ying Yue,a   Chen-Guo Feng, ORCID logo *b   Yingbin Liu*a  and  Guo-Qiang Linb  

* Corresponding authors

a State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
E-mail: laoniulyb@shsmu.edu.cn

b The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China
E-mail: fengcg@shutcm.edu.cn

Abstract

A convenient method for synthesizing aryl-containing trisubstituted alkenes through direct alkylation of alkenes was successfully achieved under solvent-free and catalyst-free conditions. The absence of solvents was found to be crucial in initiating this sequence. Moreover, this protocol stands out due to its minimal waste production and straightforward operation. The radical capture experiment provided evidence for an ionic reaction mechanism.

Graphical abstract: Solvent-free and catalyst-free direct alkylation of alkenes

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Article information

DOI
https://doi.org/10.1039/D3GC02685J
Article type
Communication
Submitted
22 júl 2023
Accepted
11 aug 2023
First published
15 aug 2023

Green Chem., 2023,25, 7073-7078

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Solvent-free and catalyst-free direct alkylation of alkenes

M. Li, J. Li, A. Gu, X. Nong, S. Zhai, Z. Yue, C. Feng, Y. Liu and G. Lin, Green Chem., 2023, 25, 7073 DOI: 10.1039/D3GC02685J

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