HP(O)Ph2/H2O-promoted hydrodefluorination of trifluoromethyl alkenes

Xue-Qiang Chu; Li-Wen Sun; Yu-Lan Chen; Jia-Wei Chen; Xuan Ying; Mengtao Ma; Zhi-Liang Shen

doi:10.1039/D1GC04645D

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HP(O)Ph₂/H₂O-promoted hydrodefluorination of trifluoromethyl alkenes†

Xue-Qiang Chu,

*^a Li-Wen Sun,^a Yu-Lan Chen,^a Jia-Wei Chen,^a Xuan Ying,^a Mengtao Ma

^b and Zhi-Liang Shen

*^a

Author affiliations

* Corresponding authors

^a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China
E-mail: xueqiangchu@njtech.edu.cn, ias_zlshen@njtech.edu.cn

^b Department of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, China

Abstract

An efficient transition-metal-free hydrodefluorination reaction of trifluoromethyl alkenes for accessing gem-difluoroalkenes is developed. It was surprising to find that the phosphoryl anion is able to mediate the defluorination. The successful realization of the reaction could also be attributed to the utility of water as an eco-friendly promoter.

This article is part of the themed collection: 2022 Green Chemistry Hot Articles

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Article information

DOI: https://doi.org/10.1039/D1GC04645D
Article type: Communication
Submitted: 13 dec 2021
Accepted: 02 mar 2022
First published: 04 mar 2022

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Green Chem., 2022,24, 2777-2782

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HP(O)Ph₂/H₂O-promoted hydrodefluorination of trifluoromethyl alkenes

X. Chu, L. Sun, Y. Chen, J. Chen, X. Ying, M. Ma and Z. Shen, Green Chem., 2022, 24, 2777 DOI: 10.1039/D1GC04645D

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