Issue 11, 2022

Semi-continuous and continuous processes for enantiomeric separation

Abstract

Chiral resolution is an operation of great interest and increasing importance for the scientific community and industry. There are two approaches to provide enantiomerically pure compounds: by asymmetric synthesis of just one of the enantiomers or by resolution of racemates consisting of separating a mixture of both enantiomers. In the past years, extraordinary progress has been achieved in continuous enantiomeric separation, implementing more efficient procedures, and contributing to developing greener and more sustainable separation processes. This review article covers the main topics and applications of semi-continuous and continuous chiral separation focusing, in particular, on preferential crystallization, membrane separations, and continuous chromatography. It also offers an authors’ perspective on potential future directions in the field.

Graphical abstract: Semi-continuous and continuous processes for enantiomeric separation

Article information

Article type
Tutorial Review
Submitted
05 okt 2021
Accepted
08 feb 2022
First published
20 máj 2022
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2022,24, 4328-4362

Semi-continuous and continuous processes for enantiomeric separation

M. Ciriani, R. Oliveira and C. A. M. Afonso, Green Chem., 2022, 24, 4328 DOI: 10.1039/D1GC03668H

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