Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Lili Huang; Peter Kam-Keung Leung; Lawrence Cho-Cheung Lee; Guang-Xi Xu; Yun-Wah Lam; Kenneth Kam-Wing Lo

doi:10.1039/D2CC02405E

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Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications†

Lili Huang,

^a Peter Kam-Keung Leung,

^ab Lawrence Cho-Cheung Lee,

^ac Guang-Xi Xu,

^a Yun-Wah Lam

*^a and Kenneth Kam-Wing Lo

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China
E-mail: bhkenlo@cityu.edu.hk

^b State Key Laboratory of Terahertz and Millimetre Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China

^c Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503 – 1511, 15/F, Building 17W, Hong Kong Science Park, New Territories, Hong Kong, P. R. China

Abstract

We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

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Article information

DOI: https://doi.org/10.1039/D2CC02405E
Article type: Communication
Submitted: 28 apr 2022
Accepted: 05 aug 2022
First published: 08 aug 2022

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Chem. Commun., 2022,58, 10162-10165

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Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

L. Huang, P. K. Leung, L. C. Lee, G. Xu, Y. Lam and K. K. Lo, Chem. Commun., 2022, 58, 10162 DOI: 10.1039/D2CC02405E

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Chemical Communications

Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications†

Abstract

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Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

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