Issue 50, 2022

Triazine-pyridine chemistry for protein labelling on tyrosine

Abstract

Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems after cysteine blocking, displayed potential in tyrosine-guided protein labelling, and had bio-compatibility in live cells.

Graphical abstract: Triazine-pyridine chemistry for protein labelling on tyrosine

Supplementary files

Article information

Article type
Communication
Submitted
17 mar 2022
Accepted
23 máj 2022
First published
24 máj 2022

Chem. Commun., 2022,58, 7066-7069

Triazine-pyridine chemistry for protein labelling on tyrosine

H. Jiang, Q. Zhang, Y. Zhang, H. Feng, H. Jiang, F. Pu, R. Yu, Z. Zhong, C. Wang, Y. M. E. Fung, P. Blasco, Y. Li, T. Jiang and X. Li, Chem. Commun., 2022, 58, 7066 DOI: 10.1039/D2CC01528E

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