Nematicidal activity of naphthalimide–boron cluster conjugates

Anna Bogucka-Kocka; Przemysław Kołodziej; Anna Makuch-Kocka; Daria Różycka; Sebastian Rykowski; Jan Nekvinda; Bohumír Grüner; Agnieszka B. Olejniczak

doi:10.1039/D1CC07075D

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Nematicidal activity of naphthalimide–boron cluster conjugates†‡

Anna Bogucka-Kocka,

^a Przemysław Kołodziej,

^a Anna Makuch-Kocka,

^b Daria Różycka,

§^c Sebastian Rykowski,

§^c Jan Nekvinda,

^d Bohumír Grüner

^d and Agnieszka B. Olejniczak

*^c

Author affiliations

* Corresponding authors

^a Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chodźki St., Lublin 20-093, Poland

^b Chair of Pharmacology and Biology, Department of Pharmacology, Medical University of Lublin, 4a Chodźki St., Lublin 20-093, Poland

^c Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., Lodz 93-232, Poland
E-mail: aolejniczak@cbm.pan.pl

^d Institute of Inorganic Chemistry, Czech Academy of Sciences, Hlavní 1001, CZ-250 68 Řež, Czech Republic

Abstract

This study presents the activity of a series of 1,8-naphthalimide–carborane/metallacarborane conjugates against Rhabditis sp. The carborane conjugates were the least active. Selected conjugates with cobaltacarborane (5 and 6) showed high activity. Their lethal concentration (LC₅₀) values are substantially lower than that of the drug mebendazole.

This article is part of the themed collection: Boron Chemistry in the 21st Century: From Synthetic Curiosities to Functional Molecules

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DOI: https://doi.org/10.1039/D1CC07075D
Article type: Communication
Submitted: 16 dec 2021
Accepted: 17 jan 2022
First published: 19 jan 2022

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Chem. Commun., 2022,58, 2528-2531

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Nematicidal activity of naphthalimide–boron cluster conjugates

A. Bogucka-Kocka, P. Kołodziej, A. Makuch-Kocka, D. Różycka, S. Rykowski, J. Nekvinda, B. Grüner and A. B. Olejniczak, Chem. Commun., 2022, 58, 2528 DOI: 10.1039/D1CC07075D

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Chemical Communications

Nematicidal activity of naphthalimide–boron cluster conjugates†‡

Abstract

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Nematicidal activity of naphthalimide–boron cluster conjugates

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