Issue 19, 2022

Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

Abstract

Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials. In particular, their hierarchical pore structures, variable morphologies, and tunable biological properties make them suitable as drug-delivery systems. In this review, the synthetic and post forming/control methods including templated methods, template-free methods, mechanical methods, electrospun methods, and 3D printing methods for controlling the hierarchical structures and morphologies of porous organic polymers are discussed, and the different methods affecting their specific surface areas, hierarchical structures, and unique morphologies are highlighted in detail. In addition, we discuss their applications in drug encapsulation and the development of stimuli (pH, heat, light, and dual-stimuli)-responsive materials, focusing on their use for targeted drug release and as therapeutic agents. Finally, we present an outlook concerning the research directions and applications of porous polymer-based drug delivery systems.

Graphical abstract: Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

Article information

Article type
Review Article
Submitted
09 máj 2022
Accepted
11 júl 2022
First published
15 júl 2022

Biomater. Sci., 2022,10, 5369-5390

Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

Y. Tang, A. Varyambath, Y. Ding, B. Chen, X. Huang, Y. Zhang, D. Yu, I. Kim and W. Song, Biomater. Sci., 2022, 10, 5369 DOI: 10.1039/D2BM00719C

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