Issue 30, 2021

Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection

Abstract

Nesfatin-1 (NES1) is a potential biomarker found in serum and saliva that indicates hyperpolarization and depolarization in the hypothalamic ventricle nucleus as well as an increase in epileptic conditions. However, real-time investigations have not been carried out to detect changes in the concentration of NES1. In this study, we develop a multiscale pore contained carbon nanofiber-based field-effect transistor (FET) biosensor to detect NES1. The activated multiscale pore contained carbon nanofiber (a-MPCNF) is generated using a single-nozzle co-electrospinning method and a subsequent steam-activation process to obtain a signal transducer and template for immobilization of bioreceptors. The prepared biosensor exhibits a high sensitivity to NES1. It can detect levels as low as 0.1 fM of NES1, even in the presence of other interfering biomolecules. Furthermore, the a-MPCNF-based FET sensor has significant potential for practical applications in non-invasive real-time diagnosis, as indicated by its sensing performance in artificial saliva.

Graphical abstract: Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection

Supplementary files

Article information

Article type
Paper
Submitted
18 mar 2021
Accepted
30 jún 2021
First published
30 jún 2021

J. Mater. Chem. B, 2021,9, 6076-6083

Multiscale pore contained carbon nanofiber-based field-effect transistor biosensors for nesfatin-1 detection

S. G. Kim and J. S. Lee, J. Mater. Chem. B, 2021, 9, 6076 DOI: 10.1039/D1TB00582K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements