Issue 2, 2021
From the journal:

RSC Chemical Biology

Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor†

Kaho Suzuki,a   Yousuke Takaoka ORCID logo *a  and  Minoru Ueda ORCID logo *ab  

* Corresponding authors

a Graduate School of Science, Tohoku University, 6-3, Aramaki-Aza-Aoba, Aoba-ku, Sendai, Japan
E-mail: ytakaoka@tohoku.ac.jp

b Graduate School of Life Science, Tohoku University, 6-3, Aramaki-Aza-Aoba, Aoba-ku, Sendai, Japan

Abstract

We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.

Graphical abstract: Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor

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Article information

DOI
https://doi.org/10.1039/D0CB00204F
Article type
Communication
Submitted
12 nov 2020
Accepted
14 dec 2020
First published
05 jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 499-502

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Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor

K. Suzuki, Y. Takaoka and M. Ueda, RSC Chem. Biol., 2021, 2, 499 DOI: 10.1039/D0CB00204F

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