Issue 32, 2019

Fatty acid based transient nanostructures for temporal regulation of artificial peroxidase activity

Abstract

Natural systems access transient high energy self-assembled structures for temporal regulation of different biological functions through dissipative processes. Compartmentalization within self-assembled structures is used by living systems to organize vital biochemical reactions that define cellular metabolism. Herein, we demonstrate a simple fatty acid based system where a redox active base (dimethylaminomethyl ferrocene, Fc-NMe2) acts as a countercation to access unique hexagonal compartments resulting in the formation of a self-supporting gel. An oxidizing environment helps in the dissipation of energy by converting Fc-NMe2 to oxidized waste and the gel autonomously undergoes transition to a sol. Hence, the system requires the addition of the fuel Fc-NMe2 to access the temporal gel state. Notably, these transient compartments were able to temporally upregulate and downregulate hemin-catalyzed oxidation reactions mimicking peroxidase, a ubiquitous enzyme in extant biology. An order of magnitude variation in kcat values was observed with time and the chemical reaction persists as long as the gel state was present.

Graphical abstract: Fatty acid based transient nanostructures for temporal regulation of artificial peroxidase activity

Supplementary files

Article information

Article type
Edge Article
Submitted
31 máj 2019
Accepted
21 jún 2019
First published
01 júl 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2019,10, 7574-7578

Fatty acid based transient nanostructures for temporal regulation of artificial peroxidase activity

S. Ahmed, A. Chatterjee, K. Das and D. Das, Chem. Sci., 2019, 10, 7574 DOI: 10.1039/C9SC02648G

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