Issue 34, 2019

Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids

Abstract

Herein, we report three-component vicinal-diarylation of non-conjugated alkenes initiated by transmetalation of arylboronic acids, which provides complementary access to β,γ-diaryl carbonyl compounds. We have also screened a large number of chiral ligands for developing an enantioselective version of this reaction and obtained the preliminary results (up to 79 : 21 e.r.). Notably, the methodology developed herein represents the first three component syn-vicinal-dicarbofunctionalization of non-conjugated alkenes involving palladium catalysis.

Graphical abstract: Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids

Supplementary files

Article information

Article type
Edge Article
Submitted
05 máj 2019
Accepted
03 júl 2019
First published
03 júl 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2019,10, 7952-7957

Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids

Y. Zhang, G. Chen and D. Zhao, Chem. Sci., 2019, 10, 7952 DOI: 10.1039/C9SC02182E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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