Issue 7, 2019

Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products

Abstract

Covering: up to 2019

The discovery of new bioactive natural products gained momentum during the last few decades, resulting from instrumentation advances, from the expansion of genome mining and regulation, as well as by exploration of untapped biological sources. However, water-soluble, volatile, minor and photosensitive natural products are yet poorly known. This review discusses the literature reporting the isolation strategies for some of these metabolites. Analysis of minor metabolites at sub-milligram level are also presented, since analytical instrumentation enabling structure assignment in minute quantities is now routine. Major trends related to natural products discovery are discussed, under the light of further developments in biodiscovery.

Graphical abstract: Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products

Article information

Article type
Review Article
Submitted
01 feb 2019
First published
03 máj 2019

Nat. Prod. Rep., 2019,36, 981-1004

Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products

R. G. S. Berlinck, A. F. Monteiro, A. F. Bertonha, D. I. Bernardi, J. R. Gubiani, J. Slivinski, L. F. Michaliski, L. A. C. Tonon, V. A. Venancio and V. F. Freire, Nat. Prod. Rep., 2019, 36, 981 DOI: 10.1039/C9NP00009G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements