Issue 1, 2018

Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

Abstract

The transfer of pathogens from contaminated surfaces to patients is one of the main causes of health care-associated infections (HCAIs). Cases of HCAIs due to multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for the prevention and control of HCAIs. Here, we present a cesium salt of phosphotungstic heteropolyacid (Cs2.5H0.5PW12O40) as a promising nanomaterial for use in antimicrobial product technologies. This water-insoluble Keggin salt exhibits a broad biocide spectrum against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi even under dark conditions. The Cs2.5H0.5PW12O40 nanoparticles (NPs) act as a proton-regulated antimicrobial whose activity is mediated on the release of hydronium ions (H3O+), yielding an in situ acidic pH several units below those tolerable by most of the fungal and bacterial nosocomial pathogens.

Graphical abstract: Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

Supplementary files

Article information

Article type
Paper
Submitted
20 okt 2017
Accepted
01 dec 2017
First published
01 dec 2017

J. Mater. Chem. B, 2018,6, 143-152

Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

R. H. Piva, M. C. Rocha, D. H. Piva, O. R. K. Montedo, H. Imasato, I. Malavazi and U. P. Rodrigues-Filho, J. Mater. Chem. B, 2018, 6, 143 DOI: 10.1039/C7TB02763J

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