A unimolecular theranostic system with H2O2-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

Xiaoying Gao; Jie Cao; Yinuo Song; Xiao Shu; Jianzhao Liu; Jing Zhi Sun; Bin Liu; Ben Zhong Tang

doi:10.1039/C8RA01185K

A unimolecular theranostic system with H₂O₂-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells†

Xiaoying Gao,^a Jie Cao,^a Yinuo Song,^a Xiao Shu,^a Jianzhao Liu,*^a Jing Zhi Sun,

^a Bin Liu

*^b and Ben Zhong Tang*^acd

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: liujz@zju.edu.cn

^b Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, Singapore
E-mail: cheliub@nus.edu.sg

^c Department of Chemistry, Division of Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

^d SCUT-HKUST Joint Research Laboratory, Guangdong Innovative Research Team, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, China

Abstract

A theranostic drug delivery system composed of tetraphenyl-ethene (AIEgen), benzyl boronic ester (trigger), and doxorubicin (drug) was designed and synthesized; its utilities for cell imaging, drug delivery tracking, and cancer cell cytociding were evaluated.

This article is part of the themed collection: Editors’ collection: Fluorescent Sensors

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Article information

DOI: https://doi.org/10.1039/C8RA01185K
Article type: Paper
Submitted: 07 feb 2018
Accepted: 14 mar 2018
First published: 20 mar 2018
This article is Open Access

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RSC Adv., 2018,8, 10975-10979

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A unimolecular theranostic system with H₂O₂-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

X. Gao, J. Cao, Y. Song, X. Shu, J. Liu, J. Z. Sun, B. Liu and B. Z. Tang, RSC Adv., 2018, 8, 10975 DOI: 10.1039/C8RA01185K

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