A concise synthesis of indene-based polycyclic compounds via FeCl3-catalyzed cascade cyclization

Xiang Su; Panpan Wu; Wenfeng Liu; Chao Chen

doi:10.1039/C8QO00004B

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A concise synthesis of indene-based polycyclic compounds via FeCl₃-catalyzed cascade cyclization†

Xiang Su,^a Panpan Wu,^bc Wenfeng Liu^bc and Chao Chen

*^abc

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* Corresponding authors

^a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: chenchao01@mails.tsinghua.edu.cn

^b School of Chemical & Environmental Engineering, Wuyi University, Jiangmen, China

^c International Healthcare Innovation Institute (Jiangmen), Jiangmen, China

Abstract

An efficient and straightforward protocol to complex indene-based polycyclic compounds via the cascade cyclization of propargylic alcohols and alkenes was developed. The catalyst FeCl₃, as an Earth-abundant and environment friendly transition metal salt, is attractive. This reaction proceeded through unusual C–C bond cleavage.

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Article information

DOI: https://doi.org/10.1039/C8QO00004B
Article type: Research Article
Submitted: 03 jan 2018
Accepted: 23 jan 2018
First published: 24 jan 2018

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Org. Chem. Front., 2018,5, 1165-1169

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A concise synthesis of indene-based polycyclic compounds via FeCl₃-catalyzed cascade cyclization

X. Su, P. Wu, W. Liu and C. Chen, Org. Chem. Front., 2018, 5, 1165 DOI: 10.1039/C8QO00004B

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