Issue 22, 2018

DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

Abstract

Novel tinidazole (tnz) coordination compounds of different geometries were synthesised, whose respective solid-state packing appears to be driven by inter- and intramolecular lone pair⋯π interactions. The copper(II) compounds exhibit interesting redox properties originating from both the tnz and the metal ions. These complexes interact with DNA through two distinct ways, namely via electrostatic interactions or/and groove binding, and they can mediate the generation of ROS that damage the biomolecule. Cytotoxic studies revealed an interesting activity of the dinuclear compound [Cu(tnz)2(μ-Cl)Cl]27, which is further more efficient towards cancer cells, compared with normal cells.

Graphical abstract: DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

Supplementary files

Article information

Article type
Paper
Submitted
22 feb 2018
Accepted
09 máj 2018
First published
09 máj 2018

Dalton Trans., 2018,47, 7551-7560

DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic properties

R. Castro-Ramírez, N. Ortiz-Pastrana, A. B. Caballero, M. T. Zimmerman, B. S. Stadelman, A. A. E. Gaertner, J. L. Brumaghim, L. Korrodi-Gregório, R. Pérez-Tomás, P. Gamez and N. Barba-Behrens, Dalton Trans., 2018, 47, 7551 DOI: 10.1039/C8DT00716K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements