Issue 39, 2018

Hygroscopicity of lithium coordination polymers and their solid solutions

Abstract

Coordination polymers (CPs) of active pharmaceutical ingredients (APIs) are relatively rare, though recent studies show how these forms can afford improved solubility and stability. Here, the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their potential utility as drug substances. In particular, the solid solutions of {[(PRO)Li(MBNZ)1−x(BNZ)x]}n (1x) show lower stability than both the pure compounds whereas in the solid solutions of {[Li2(SUC)1−x(MAL)x]}n (2x), the hygroscopicity varies more regularly with composition.

Graphical abstract: Hygroscopicity of lithium coordination polymers and their solid solutions

Supplementary files

Article information

Article type
Communication
Submitted
31 máj 2018
Accepted
27 júl 2018
First published
27 júl 2018

CrystEngComm, 2018,20, 5940-5944

Hygroscopicity of lithium coordination polymers and their solid solutions

M. Lestari, M. Lusi, A. O'Leary, D. O'Nolan and M. J. Zaworotko, CrystEngComm, 2018, 20, 5940 DOI: 10.1039/C8CE00905H

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