Issue 50, 2018

Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

Abstract

Since the first isolation of pseurotin A in 1976, over twenty five spirocyclic PKS-NRPS-based (polyketide synthase-nonribosomal peptide synthetase-based) fungal natural products have been discovered to date. The common 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione core of this family of natural products has served as a platform for the development of novel chemistry and resulted in the development of numerous new reactivities and synthetic strategies. Herein, we delineate all reported syntheses of spirocyclic PKS-NRPS-based fungal metabolites including our own recent contributions on this subject. We showcase how a biosynthetic consideration could lead to concise synthetic routes to this family of natural products.

Graphical abstract: Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

Article information

Article type
Feature Article
Submitted
23 mar 2018
Accepted
30 máj 2018
First published
30 máj 2018

Chem. Commun., 2018,54, 6750-6758

Total syntheses of spirocyclic PKS-NRPS-based fungal metabolites

D. Jo and S. Han, Chem. Commun., 2018, 54, 6750 DOI: 10.1039/C8CC02315H

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