A two-photon fluorescent probe for ratiometric imaging of endogenous hypochlorous acid in live cells and tissues†
Yong Woong
Jun, 
‡a
Sourav
Sarkar,
‡a
Subhankar
Singha,
*a
Ye Jin
Reo,
a
Young-Tae
Chang
*ab
and
Kyo Han
Ahn
*a
‡a
Sourav
Sarkar,
‡a
Subhankar
Singha,
*a
Ye Jin
Reo,
a
Young-Tae
Chang
*ab
and
Kyo Han
Ahn
*a
Abstract
A fluorescent probe that enables ratiometric imaging of endogenous hypochlorous acid (HOCl) in cells and tissues by two-photon microscopy is developed based on a red-emitting acetyl-benzocoumarin (AcBC) dye. An oxathiolane group in the probe reacts with HOCl to generate the AcBC dye, which involves a ratiometric fluorescence change only toward HOCl along with high sensitivity.
- This article is part of the themed collection: Chemosensors and Molecular Logic
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