Issue 7, 2016

Catalytic asymmetric α-amination of β-keto esters and β-keto amides with a chiral N,N′-dioxide–copper(i) complex

Abstract

The highly efficient asymmetric α-amination of β-keto esters and β-keto amides was realized by using a chiral N,N′-dioxide/Cu(I) complex. Under mild reaction conditions, a series of corresponding chiral α-amino dicarbonyl compounds were obtained in excellent yields (up to 98%) with excellent enantioselectivities (up to 95% ee).

Graphical abstract: Catalytic asymmetric α-amination of β-keto esters and β-keto amides with a chiral N,N′-dioxide–copper(i) complex

Supplementary files

Article information

Article type
Research Article
Submitted
08 mar 2016
Accepted
27 apr 2016
First published
09 máj 2016

Org. Chem. Front., 2016,3, 809-812

Catalytic asymmetric α-amination of β-keto esters and β-keto amides with a chiral N,N′-dioxide–copper(I) complex

X. Xiao, L. Lin, X. Lian, X. Liu and X. Feng, Org. Chem. Front., 2016, 3, 809 DOI: 10.1039/C6QO00095A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements