Issue 6, 2016

Low-valent cobalt-catalyzed C–H allylation

Abstract

An efficient allylation of C–H bonds promoted by a simple cobalt salt combined with a Grignard reagent has been developed. This reaction provides an alternative protocol to the build-up of fundamentally interesting allylated aromatics at room temperature. Mechanistically different from the Cp*Co(III)-promoted transformation, a low-valent cobalt complex that was formed in situ by the reduction with a Grignard reagent can be considered as the catalytically active species, allowing the C–H activation to proceed effectively followed by straightforward coupling with an allylic electrophile to give the product.

Graphical abstract: Low-valent cobalt-catalyzed C–H allylation

Supplementary files

Article information

Article type
Research Article
Submitted
12 jan 2016
Accepted
16 mar 2016
First published
18 mar 2016

Org. Chem. Front., 2016,3, 673-677

Low-valent cobalt-catalyzed C–H allylation

X. Cong, S. Zhai and X. Zeng, Org. Chem. Front., 2016, 3, 673 DOI: 10.1039/C6QO00011H

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