Issue 4, 2016

Palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonate

Abstract

An efficient palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosophonate is described. The method provides a facile access to a series of phosphonyldifluoromethylated alkenes that are of interest in medicinal chemistry. Mechanistic studies reveal that a phosphonyl difluouromethyl radical is involved in the reaction.

Graphical abstract: Palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonate

Supplementary files

Article information

Article type
Research Article
Submitted
06 jan 2016
Accepted
28 jan 2016
First published
29 jan 2016
This article is Open Access
Creative Commons BY license

Org. Chem. Front., 2016,3, 466-469

Palladium-catalyzed phosphonyldifluoromethylation of alkenes with bromodifluoromethylphosphonate

Z. Feng, Y. Xiao and X. Zhang, Org. Chem. Front., 2016, 3, 466 DOI: 10.1039/C6QO00005C

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