Issue 2, 2016

Palladium-catalysed coupling reaction of aminals with N-sulfonyl hydrazones to give allylic sulfones

Abstract

Palladium-catalysed cross-coupling of aminals with N-sulfonyl hydrazones has been established via C–N bond activation under base-free conditions, in which one C–C bond and one C–S bond were simultaneously generated. It was successfully applied in the construction of a variety of aminomethyl substituted allylic sulfones. Preliminary mechanistic studies indicated that the unique electrophilic cyclopalladated complex was involved in the catalytic cycle.

Graphical abstract: Palladium-catalysed coupling reaction of aminals with N-sulfonyl hydrazones to give allylic sulfones

Supplementary files

Article information

Article type
Research Article
Submitted
18 nov 2015
Accepted
20 dec 2015
First published
22 dec 2015

Org. Chem. Front., 2016,3, 259-267

Author version available

Palladium-catalysed coupling reaction of aminals with N-sulfonyl hydrazones to give allylic sulfones

J. Li, G. Qin, Y. Liu and H. Huang, Org. Chem. Front., 2016, 3, 259 DOI: 10.1039/C5QO00381D

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