Issue 48, 2015
From the journal:

RSC Advances

Rational design of Au nanorods assemblies for highly sensitive and selective SERS detection of prostate specific antigen†

An-qi Yang,a   Dong Wang, ORCID logo ab   Xiang Wang,b   Yu Han,a   Xue-bin Ke,a   Hong-jun Wang,c   Xi Zhou*a  and  Lei Ren*ab  

* Corresponding authors

a Department of Biomaterials, College of Materials, Xiamen University, Xiamen, People's Republic of China
E-mail: xizhou@xmu.edu.cn, renlei@xmu.edu.cn
Fax: +86-5922183937
Tel: +86-5922188530

b State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, People's Republic of China

c Department of Chemistry, Chemical Biology and Biomedical Engineering, Stevens Institute of Technology, 1 Castle Point on Hudson, Hoboken, New Jersey, USA

Abstract

A versatile approach for highly sensitive surface-enhanced Raman scattering (SERS) detection of prostate specific antigen (PSA) has been developed based on immune recognition assisted fabrication of gold nanorods (AuNRs) assemblies. Compared with the typical enzyme-linked immunosorbent assay, this SERS immunoassay strategy showed an obviously enhanced sensitivity. The SERS immunoassay for PSA detection has also been successfully applied in diluted human serum samples, showing the promising potential for early diagnosis of diseases in clinical application.

Graphical abstract: Rational design of Au nanorods assemblies for highly sensitive and selective SERS detection of prostate specific antigen

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Article information

DOI
https://doi.org/10.1039/C5RA01322D
Article type
Paper
Submitted
22 jan 2015
Accepted
20 apr 2015
First published
20 apr 2015
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2015,5, 38354-38360

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Rational design of Au nanorods assemblies for highly sensitive and selective SERS detection of prostate specific antigen

A. Yang, D. Wang, X. Wang, Y. Han, X. Ke, H. Wang, X. Zhou and L. Ren, RSC Adv., 2015, 5, 38354 DOI: 10.1039/C5RA01322D

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