Issue 75, 2015

Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor

Abstract

The concept of enzyme immobilization via an inhibitor-derived peptide was developed. This method of immobilization was shown to be advantageous over physical adsorption and covalent bonding in retaining the enzymatic activity. Moreover, the surface-immobilized enzyme exhibited resistance against its inhibitor due to the occupation of an inhibitor binding site on the enzyme.

Graphical abstract: Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor

Supplementary files

Article information

Article type
Communication
Submitted
08 júl 2015
Accepted
30 júl 2015
First published
31 júl 2015

Chem. Commun., 2015,51, 14263-14266

Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor

Z. Tang, Y. Luan, D. Li, H. Du, D. M. Haddleton and H. Chen, Chem. Commun., 2015, 51, 14263 DOI: 10.1039/C5CC05652G

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