Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation

Sandani Samarajeewa; Ryan P. Zentay; Nema D. Jhurry; Ang Li; Kellie Seetho; Jiong Zou; Karen L. Wooley

doi:10.1039/C3CC46013D

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Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation†

Sandani Samarajeewa,^a Ryan P. Zentay,^a Nema D. Jhurry,^a Ang Li,^a Kellie Seetho,^a Jiong Zou^a and Karen L. Wooley*^a

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* Corresponding authors

^a Departments of Chemistry and Chemical Engineering, Texas A&M University, P. O. Box 30012, College Station, Texas, USA
E-mail: wooley@chem.tamu.edu
Fax: +1 (979) 862-1137
Tel: +1 (979) 845-4077

Abstract

Electrostatic interaction-mediated enzymatic-hydrolysis of poly(lactide)-containing nanoscale assemblies is described. At physiological pH, degradable core–shell morphologies with charged shells can readily attract or repel enzymes carrying opposite or similar charges, respectively.

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DOI: https://doi.org/10.1039/C3CC46013D
Article type: Communication
Submitted: 06 aug 2013
Accepted: 25 nov 2013
First published: 04 dec 2013

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Chem. Commun., 2014,50, 968-970

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Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation

S. Samarajeewa, R. P. Zentay, N. D. Jhurry, A. Li, K. Seetho, J. Zou and K. L. Wooley, Chem. Commun., 2014, 50, 968 DOI: 10.1039/C3CC46013D

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Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation†

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