Issue 34, 2011

Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue§

Abstract

The glycan moiety of ganglioside HPG-7, isolated from the sea cucumber (Holothuria pervicax), was synthesized for the first time. The characteristic substructure, a trisialic acid sequence embedded in the glycan, was deliberately constructed by utilizing suitably differentiated sialyl units for various synthetic purposes. Finally, a pentasaccharide was successfully delivered as the hexyl glycoside.

Graphical abstract: Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue

Supplementary files

Article information

Article type
Communication
Submitted
31 máj 2011
Accepted
11 júl 2011
First published
21 júl 2011

Chem. Commun., 2011,47, 9726-9728

Synthesis of the glycan moiety of ganglioside HPG-7 with an unusual trimer of sialic acid as the inner sugar residue

Y. Iwayama, H. Ando, H. Tanaka, H. Ishida and M. Kiso, Chem. Commun., 2011, 47, 9726 DOI: 10.1039/C1CC13200H

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