Issue 33, 2011

Targeted pH-dependent fluorescent activity-based cathepsin probes

Abstract

Bifunctional, pH-activatable BODIPY dyes were developed and incorporated in mannose cluster-containing activity-based probes for cysteine proteases. Mannose receptor-dependent uptake of the probes in dendritic cells, followed by trafficking to acidic cellular compartments resulted in fluorescence as seen by live-cell imaging, and subsequent cathepsin inhibition.

Graphical abstract: Targeted pH-dependent fluorescent activity-based cathepsin probes

Supplementary files

Article information

Article type
Communication
Submitted
19 máj 2011
Accepted
29 jún 2011
First published
18 júl 2011

Chem. Commun., 2011,47, 9363-9365

Targeted pH-dependent fluorescent activity-based cathepsin probes

S. Hoogendoorn, K. L. Habets, S. Passemard, J. Kuiper, G. A. van der Marel, B. I. Florea and H. S. Overkleeft, Chem. Commun., 2011, 47, 9363 DOI: 10.1039/C1CC12947C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements