Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies
Abstract
Syntheses of
6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol 10 and
1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol 34
are described. The aryl phosphonic acid 14, which can be used as
a linker to a protein, is synthesised and coupled to the above
alcohols. These haptens, when linked to a protein, are intended
to generate antibodies able to catalyse cationic cyclisation
reactions.
- This article is part of the themed collection: In memory of Chris Abell
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