Asymmetric catalytic intramolecular hydroacylation of 4-substituted pent-4-enals to β-substituted cyclopentanones
Abstract
The catalyst,
[Rh(S,S-Me-duphos)(acetone)
2
]
+
, rapidly and
efficiently converts 4-substituted pent-4-enals bearing primary and
secondary substituents to the corresponding cyclopentanones and for a
variety of substituents the ee was found to range from 93 to 96% at 25
°C.
- This article is part of the themed collection: RACI100: Celebrating Australian Chemistry
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