Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging

Jingjing Shen; Wenwen Shi; Guan Liu; Wei Zhuang; Kang Wang; Yi Wang; Kangquan Shou; Weibing Wu; Xiaowen Liu; Quli Fan; Lei Zhang

doi:10.1039/D3TB00760J

Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging

Jingjing Shen,†^a Wenwen Shi,†^a Guan Liu,^a Wei Zhuang,^a Kang Wang,^a Yi Wang,^a Kangquan Shou,^b Weibing Wu,

*^c Xiaowen Liu,^d Quli Fan

*^a and Lei Zhang

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China
E-mail: iamqlfan@njupt.edu.cn, iamlzhang@njupt.edu.cn

^b Department of Orthopedic, the First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang 443000, China

^c Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China
E-mail: wbwu@njfu.edu.cn

^d Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Medical College, China Three Gorges University, Yichang 443000, China

Abstract

A photoacoustic imaging (Au@PDA-WL NPs) probe was successfully prepared for monitoring the early degeneration of articular cartilage. WYRGRL immobilized on the surface of Au@PDA NPs could target the collagen II peptide, which is expressed on chondrocytes in vivo and in vitro, and the enrichment of this nano-probe on cartilage tissue further resulted in the localized plasmon resonance coupling effect, inducing an enhancement in photothermal conversion capacity after the formation of aggregates. Besides, the catechol structure in the PDA shell could eliminate ROS to effectively delay the development of osteoarthrosis.

This article is part of the themed collection: Journal of Materials Chemistry B HOT Papers

Journal of Materials Chemistry B

Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging

Abstract

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Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging

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