Issue 44, 2020

Salient features of medical nanoparticles in biological fluids from an analytical ultracentrifuge

Abstract

From the perspective of future translation, medical, biodegradable nanoparticles (NPs) have been investigated using an analytical ultracentrifuge in fluids of various complexity, including human serum, in the temperature range of 6 to 40 °C, and timescales relevant for a nanomedical targeting and clearance application. These studies provided salient insights into the integrity and degradation aspects of the NPs, imposed by varying solution environmental conditions. This was enabled by selective monitoring of the targeting dye moiety, cell-specifically directing the NPs to the desired location of interest, i.e. considering a future translative in vivo application. Our study provides experimental insights that are believed to be of key importance to gauge the feasibility of such translative applications in terms of (i) compatibility with patient sera, (ii) timescales of targeting success, and (iii) timescales of desired erosion enabling clearance from the target. All such aspects are provided a priori any in vivo implementation.

Graphical abstract: Salient features of medical nanoparticles in biological fluids from an analytical ultracentrifuge

Supplementary files

Article information

Article type
Communication
Submitted
25 aug 2020
Accepted
08 okt 2020
First published
08 okt 2020

Nanoscale, 2020,12, 22462-22466

Salient features of medical nanoparticles in biological fluids from an analytical ultracentrifuge

G. Cinar, C. Englert, U. S. Schubert and I. Nischang, Nanoscale, 2020, 12, 22462 DOI: 10.1039/D0NR06153K

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