Issue 7, 2018
From the journal:

Organic Chemistry Frontiers

Synthesis of chiral γ-aminophosphonates through the organocatalytic hydrophosphonylation of azadienes with phosphites†

Zheng Gu, ORCID logo ab   Ji Zhou, ORCID logo a   Guo-Fang Jiang ORCID logo *a  and  Yong-Gui Zhou ORCID logo *b  

* Corresponding authors

a State Key Lab of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: gfjiang@hnu.edu.cn

b State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China
E-mail: ygzhou@dicp.ac.cn
Web: http://www.lac.dicp.ac.cn/

Abstract

An organocatalytic enantioselective 1,4-addition of phosphites to azadienes has been successfully developed using quinine as a catalyst, providing an efficient and facile route to optically active γ-aminophosphonates with up to 94% ee.

Graphical abstract: Synthesis of chiral γ-aminophosphonates through the organocatalytic hydrophosphonylation of azadienes with phosphites

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Article information

DOI
https://doi.org/10.1039/C7QO01158J
Article type
Research Article
Submitted
27 dec 2017
Accepted
27 jan 2018
First published
29 jan 2018

Org. Chem. Front., 2018,5, 1148-1151

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Synthesis of chiral γ-aminophosphonates through the organocatalytic hydrophosphonylation of azadienes with phosphites

Z. Gu, J. Zhou, G. Jiang and Y. Zhou, Org. Chem. Front., 2018, 5, 1148 DOI: 10.1039/C7QO01158J

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