Issue 5, 2018

Chitosan-catechol: a writable bioink under serum culture media

Abstract

Mussel-inspired adhesive coatings on biomedical devices have attracted significant interest due to their unique properties such as substrate independency and high efficiency. The key molecules for mussel-inspired adhesive coatings are catechol and amine groups. Along with the understanding of catechol chemistry, chitosan-catechol has also been developed as a representative mussel-inpired adhesive polymer that contains catechol and amine groups for adhesiveness. Herein, we demonstrated the direct writability of chitosan-catechol as a bioink for 3D printing, one of the additive techniques. The use of chitosan-catechol bioink results in the formation of 3D constructs in normal culture media via rapid complexation of this bioink with serum proteins; in addition, the metal/catechol combination containing tiny amounts of vanadyl ions, in which the ratio of metal to catechol is 0.0005, dramatically enhances the mechanical strength and printability of the cell-encapsulated inks, showing a cell viability of approximately 90%. These findings for mussel-inspired bioinks will be a promising way to design a biocompatible 3D bioink cross-linked without any external stimuli.

Graphical abstract: Chitosan-catechol: a writable bioink under serum culture media

Supplementary files

Article information

Article type
Paper
Submitted
12 feb 2018
Accepted
27 mar 2018
First published
04 apr 2018

Biomater. Sci., 2018,6, 1040-1047

Chitosan-catechol: a writable bioink under serum culture media

D. Lee, J. P. Park, M. Koh, P. Kim, J. Lee, M. Shin and H. Lee, Biomater. Sci., 2018, 6, 1040 DOI: 10.1039/C8BM00174J

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