Coupling of C(sp3)–H bonds with C(sp2)–O electrophiles: mild, general and selective

Yong-Yuan Gui; Li-Li Liao; Liang Sun; Zhen Zhang; Jian-Heng Ye; Guo Shen; Zhi-Peng Lu; Wen-Jun Zhou; Da-Gang Yu

doi:10.1039/C6CC09685A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Coupling of C(sp³)–H bonds with C(sp²)–O electrophiles: mild, general and selective†

Yong-Yuan Gui,^a Li-Li Liao,^a Liang Sun,^a Zhen Zhang,^a Jian-Heng Ye,^a Guo Shen,^a Zhi-Peng Lu,^a Wen-Jun Zhou^ab and Da-Gang Yu

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China
E-mail: dgyu@scu.edu.cn

^b College of Chemistry and Chemical Engineering, Neijiang Normal University, Neijiang 641112, P. R. China

Abstract

Herein is reported the mild and general coupling of amine/ether C(sp³)–H bonds with various kinds of C(sp²)–O electrophiles with high selectivity and efficiency. Valuable allylic/benzylic amines are generated in moderate to excellent yields. The utility of this transformation is demonstrated by a broad substrate scope (>50 examples), good functional group tolerance and facile product modification.

This article is part of the themed collection: Most downloaded articles of 2017: Organic and Biological Chemistry

Download options Please wait...

Supplementary files

Supplementary information PDF (6793K)

Article information

DOI: https://doi.org/10.1039/C6CC09685A
Article type: Communication
Submitted: 06 dec 2016
Accepted: 23 dec 2016
First published: 06 jan 2017

Download Citation

Chem. Commun., 2017,53, 1192-1195

Permissions

Request permissions

Coupling of C(sp³)–H bonds with C(sp²)–O electrophiles: mild, general and selective

Y. Gui, L. Liao, L. Sun, Z. Zhang, J. Ye, G. Shen, Z. Lu, W. Zhou and D. Yu, Chem. Commun., 2017, 53, 1192 DOI: 10.1039/C6CC09685A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications