Guntur Guntur, Duangkamol Gleeson, Mark Anderson, Nicole Mutter, Lauren Webster, Kevin D. Read and M. Paul Gleeson
RSC Med. Chem., 2025,16, 4796-4817
Abstract
Cheminformatics-guided optimization of the antimalarial activity and physicochemical properties of 2,4-diaminopyrimidines.
Yaqing Zhu, Fengchao Yi, Ningning Zhou, Yi Zhang, Ying Zhang, Xia Zhao and Kui Lu
Org. Biomol. Chem., 2024,22, 7024-7034
Abstract
A visible light-induced difluoroalkylation/heteroarylation of [1.1.1]propellane with nitrogen containing heterocycles and difluoroiodane(III) reagents was achieved.
Jinwei Yuan, Hongzhao Qu, Wenfeng Jia, Jinling Li, Liangru Yang, Yongmei Xiao, Yanli Yin and Lingbo Qu
Org. Biomol. Chem., 2024,22, 8904-8915
Abstract
A convenient visible-light-promoted difluoromethylation/cyclization reaction to access various difluoromethylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones was developed using [Ph3PCF2H]+Br− as a difluoromethylated reagent.
Douglas L. Orsi, Kiel E. Lazarski, Reina Improgo, R. V. Agafonov, Jae Young Ahn, Joelle Baddour, Katelyn Cassidy, Prasoon Chaturvedi, Kyle S. Cole, Richard W. Deibler, W. Austin Elam, Mark E. Fitzgerald, Victoria J. Garza, Andrew Good, Christopher H. Hulton, Marta Isasa, Katrina L. Jackson, Ping Li, Yanke Liang, Ryan E. Michael, Morgan Welzel O'Shea, Moses Moustakim, Samantha Perino, Fazlur Rahman, Matthew J. Schnaderbeck, Nicholas P. Stone, Bonnie Tillotson, Gesine K. Veits, Abigail Vogelaar, Jeremy L. Yap, Robert T. Yu, Hongwei Huang and James A. Henderson
RSC Med. Chem., 2025,16, 4781-4795
From themed collection:
Kinases
Abstract
Herein we highlight the discovery of a pan-mutant, orally bioavailable RET degrader with activity against intracranial tumors.
Muthanna Abdulkarim, Cátia Neto, Flavia Laffleur, Victor Ramos-Pérez, Andreas Bernkop-Schnürch, Salvador Gómez Borros and Mark Gumbleton
RSC Pharm., 2025,2, 1558-1579
Abstract
Densely charged but neutral sulfobetaine polymeric micelles (PMs) were designed with the aim of efficiently permeating the intestinal mucus and releasing the intact peptide cargo close to the intestinal epithelial surface.