Sijun Pan, Aixiang Ding, Yisi Li, Yaxin Sun, Yueqin Zhan, Zhenkun Ye, Ning Song, Bo Peng, Lin Li, Wei Huang and Huilin Shao
Chem. Soc. Rev., 2023,52, 5706-5743
Abstract
Integrated development of designer chemical tools and complementary analytical technologies empowers new scientific and clinical opportunities.
Sean M. McKenna, Bogdan I. Florea, Daniela M. Zisterer, Sander I. van Kasteren and Joanna F. McGouran
RSC Chem. Biol., 2024,5, 776-786
Abstract
A mercaptoquinoline based photo affinity probe for profiling metalloproteins was developed and applied in live cell assays, identifying several novel, therapeutically significant protein targets.
Lorenzo Michelini, Tanya Slaney, Seerat Virk, Estefanía Rafic, L. Charlie Qie, Klara Corejova, Mathieu L. Lepage, Stefania F. Musolino, Allen G. Oliver, Roberto Etchenique, W. David Hong, Gino A. DiLabio and Jeremy E. Wulff
Chem. Sci., 2025,16, 970-979
Abstract
A fluorene-conjugated diazirine is described, for which two-photon activation is demonstrated for the first time.
Jessica G. K. O'Brien, Louis P. Conway, Paramesh K. Ramaraj, Appaso M. Jadhav, Jun Jin, Jason K. Dutra, Parrish Evers, Shadi S. Masoud, Manuel Schupp, Iakovos Saridakis, Yong Chen, Nuno Maulide, John P. Pezacki, Christopher W. am Ende, Christopher G. Parker and Joseph M. Fox
Chem. Sci., 2024,15, 15463-15473
Abstract
Linear diazirines can produce relatively long-lived diazoalkanes which are also capable of labeling proteins whereas cyclobutanediazirines are proposed to give minimal diazo product and labeling occurs predominantly via a carbene mechanism.
Hyejin Park and Qiu Wang
Chem. Sci., 2022,13, 7378-7391
From themed collection:
2022 Chemical Science Perspective & Review Collection
Abstract
This review presents a current account of hyperpolarized 15N-labeled molecular imaging probes, as well as insights on their advantages and challenges to advance future development of 15N-based probes and their applications in MRS/MRI.