Intersystem crossing (ISC) plays a key role in the photolysis processes of oxetanes formed by benzophenone (BP)-like and thymine structures.
Despite numerous potential advantages of oxetanes, their restricted synthetic accessibility and propensity to ring-opening hamper their wide application in drug design. In this research, we have shown our solutions for this problem.
A method for the direct arylation of oxetanes was developed to address challenges with previous photoredox C–H arylation techniques, including inconsistent light sources, hazardous solvents, expensive photocatalysts, and high oxetane loadings.
A telescoped three-step sequence to functionalised spirocyclic oxetanes is reported, involving Paternò–Büchi reactions between maleic acid derivatives and cyclic ketones.
3-Aryloxetan-3-ols and 3-arylazetidin-3-ols can be selectively activated to form carbocations and allow reaction with alcohols to form ethers with the 4-membered heterocycles.