Design, synthesis, and in vitro and in silico studies of morpholine derived thiazoles as bovine carbonic anhydrase-II inhibitors

Mussarat Tasleem, Saeed Ullah, Ajmal Khan, Suraj N. Mali, Sunil Kumar, Bijo Mathew, Angelo Oneto, Faiqa Noreen, Gaber E. Eldesoky, Silvia Schenone, Ahmed Al-Harrasi and Zahid Shafiq

RSC Adv., 2024, 14, 21355
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Recent advances in the synthesis and utility of thiazoline and its derivatives

Sumit Kumar, Aditi Arora, Shivani Sapra, Rajesh Kumar, Brajendra K. Singh and Sunil K. Singh

RSC Adv., 2024, 14, 902
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Development of non-acidic 4-methylbenzenesulfonate-based aldose reductase inhibitors; Design, Synthesis, Biological evaluation and in-silicostudies

Gehad E. Said, Heba M. Metwally, Ehab Abdel-Latif, Mohamed R. Elnagar, Hany S. Ibrahim and Marwa A. Ibrahim

Bioorganic Chemistry, 2024, 151, 107666
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1,4-Naphthoquinone thiazole urea hybrids bearing morpholine/piperazine: synthesis, crystal structure, aldose reductase and α-glycosidase enzyme inhibition, molecular docking, and electrochemical interaction with dsDNA

Cagla Efeoglu, Selenay Sadak, Ertan Sahin, Yeliz Demir, Cüneyt Türkeş, Bengi Uslu and Yahya Nural

Bioorganic & Medicinal Chemistry Letters, 2026, 130, 130417
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Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 1,3,4-Thiadiazole Derivatives Targeting Both Aldose Reductase and α-Glucosidase for Diabetes Mellitus

Betül Kaya, Ulviye Acar Çevik, Adem Necip, Hatice Esra Duran, Bilge Çiftçi, Mesut Işık, Pervin Soyer, Hayrani Eren Bostancı, Zafer Asım Kaplancıklı and Şükrü Beydemir

ACS Omega, 2025
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Aldose reductase inhibition properties of novel thiazolidin-2,4-diones: In vitro and in silico approach for the treatment of diabetes-related complications

Feyzi Sinan Tokalı, Yeliz Demir, Halil Şenol, Şeyma Ateşoğlu, Pelin Tokalı, Furkan Çakır and Fahri Akbaş

Journal of Molecular Liquids, 2025, 426, 127487
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Aldose reductase and cancer metabolism: The master regulator in the limelight

NP Syamprasad, Siddhi Jain, Bishal Rajdev, Neethu Prasad, Ravindra Kallipalli and V.G.M. Naidu

Biochemical Pharmacology, 2023, 211, 115528
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An in silico Approach for Identification of Novel Natural Selective ALR2 Inhibitors from Cynomorium songaricum for Treating Diabetic Complications

Khalid Alshaghdali, Munazzah Tasleem, Talal Alharazi, Tolgahan Acar, Gamal Mohamed Elawad Ahmed, Emad Abboh, Kamal Yassin, Amre Nasr, Mohd Saeed, Dharmendra Kumar Yadav and Amir Saeed

CPD, 2026, 32, 369
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Rational designing of quinazolin-4(3H)-one based ALR2 inhibitors: Synthesis and biological evaluation

Priyanka Bhandu, Himanshu Verma, Manmeet Singh, Manoj Kumar, Gera Narendra, Shalki Choudhary, Pankaj Kumar Singh and Om Silakari

Journal of Molecular Structure, 2022, 1270, 133825
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Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors

Feyzi Sinan Tokalı, Yeliz Demir, Cüneyt Türkeş, Büşra Dinçer and Şükrü Beydemir

Drug Development Research, 2023, 84, 275
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Interaction pattern of aldose reductase with β-glucogallin: Active site exploration and multiple docking analyses

Md Ashikujjaman Ashik, Tasmia Islam, Michihiko Fujii, Md Morshedul Alam and Mohammad Nazir Hossain

Informatics in Medicine Unlocked, 2022, 30, 100938
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications

Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi and Olaitan I. Awe

Front. Bioinform., 2025, 5
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Recent advances in adamantane-linked heterocycles: synthesis and biological activity

Mohamed H. Helal, Moustafa S. Abusaif, Ahmed Ragab, Samir Y. Abbas, Radwa Ayman, Mohamed S. A. El-Gaby, Sawsan A. Fouad and Yousry A. Ammar

Mol Divers, 2025
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Synthesis of Functionalized 2‐Hydrazono‐3‐Thiazolines from 2‐Substituted Oxazoles through a One‐Pot Multicomponent/Rearrangement Process

Giovana S. Ramos, Thaís A. Rossa, Renata A. Balaguez, Ricardo I. M. Beche, Adailton J. Bortoluzzi and Marcus M. Sá

Eur J Org Chem, 2024, 27
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Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase

Gönül Yapar, Hatice Esra Duran, Nebih Lolak, Suleyman Akocak, Cüneyt Türkeş, Mustafa Durgun, Mesut Işık and Şükrü Beydemir

Bioorganic Chemistry, 2021, 117, 105473
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Mechanochemical Synthesis of Thiazolidinone-Triazoles Derivatives as Antidiabetic Agents: Pharmacokinetics, Molecular Docking, and In Vitro Antidiabetic Properties

M. B. Taj, A. Raheel, W. Alelwani, A. M. Alnajeebi, R. B. Alnoman and T. Javed

Russ J Gen Chem, 2023, 93, 912
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