Issue 41, 2009
From the journal:

Chemical Communications

NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene†

Marcus G. Schremsa  and  Andreas Pfaltz*a  

* Corresponding authors

a Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland
E-mail: andreas.pfaltz@unibas.ch
Fax: +41 61-267-1103

Abstract

Using a new class of chiral iridium hydrogenation catalysts, the antitumor natural product demethyl calamenene was synthesized in four steps in >20% overall yield and high enantiomeric purity.

Graphical abstract: NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

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Article information

DOI
https://doi.org/10.1039/B912680E
Article type
Communication
Submitted
26 Jun 2009
Accepted
14 Aug 2009
First published
27 Aug 2009

Chem. Commun., 2009, 6210-6212

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NeoPHOX—an easily accessible P,N-ligand for iridium-catalyzed asymmetric hydrogenation: preparation, scope and application in the synthesis of demethyl methoxycalamenene

M. G. Schrems and A. Pfaltz, Chem. Commun., 2009, 6210 DOI: 10.1039/B912680E

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