This review focuses on the progress in catalytic asymmetric difluoroalkylation to construction of difluoroalkylated stereogenic centers. Synthetic methods, active intermediates involved and asymmetric strategies applied were summarized.
The review summarises various photo- and electrochemical strategies for trifluoromethylation and fluoroalkylation of different C(sp3)–H, C(sp2)–H, and C(sp)–H bonds in several classes of organic molecules.
In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
Recent advances on non-precious metal-catalysed fluorination, difluorimethylation, trifluoromethylation, and perfluoroalkylation of N-heteroarenes is presented.
This review highlights the strategy of photocatalytic fluoroalkyl radical-induced cyclization for synthesizing 5–7 membered fluorinated heterocycles.