Bingchen Yu, Li Cao, Shanshan Li, Paul C. Klauser and Lei Wang
Chem. Sci., 2023,14, 7913-7921
From themed collection:
2023 Chemical Science HOT Article Collection
Abstract
Proximity-enabled SuFEx reaction between interacting proteins was found to follow a two-step mechanism. Kinetics and essential properties were thoroughly studied for SuFEx applications in protein cross-linking and covalent biotherapeutics.
Joshua A. Homer, Rebecca A. Koelln, Andrew S. Barrow, Timothy L. Gialelis, Zlata Boiarska, Nikita S. Steinohrt, Erinna F. Lee, Wen-Hsuan Yang, Robert M. Johnson, Taemoon Chung, Amber N. Habowski, Dharmendra S. Vishwakarma, Debmalya Bhunia, Charlotte Avanzi, Adam D. Moorhouse, Mary Jackson, David A. Tuveson, Scott K. Lyons, Michael J. Lukey, W. Douglas Fairlie, Shozeb M. Haider, Michel O. Steinmetz, Andrea E. Prota and John E. Moses
Chem. Sci., 2024,15, 3879-3892
From themed collection:
Celebrating the scientific accomplishments of RSC Fellows
Abstract
The Accelerated SuFEx Click Chemistry (ASCC) protocol, adapted to a 96-well plate format, has been applied to the late-stage derivatization of bioactive molecules and array synthesis of anticancer agents, showcasing its potential for drug discovery.
Hassan Seyrani, Hossein Heidarzadeh Vazifehkhorani and Victor K. Outlaw
Chem. Sci., 2025,16, 21359-21367
Abstract
SuFEx-mediated tyrosine cyclization yields stable, bioactive macrocyclic peptides under mild aqueous conditions, expanding the toolbox for peptide drug discovery.
Joseph R. Novicki, Matthew D. Teeter, Neil J. Baldwin, Christopher W. am Ende, Thomas R. Puleo, Alistair D. Richardson and Nicholas D. Ball
Chem. Sci., 2025,16, 16063-16069
From themed collection:
#MyFirstChemSci 2025
Abstract
This study reports the introduction of alkyl carbon pronucleophiles to sulfur fluoride exchange (SuFEX) exhibited by the synthesis of aryl alkyl sulfones. Parallel medicinal chemistry (PMC) is exemplified with amides, and late-stage functionalization is demonstrated with a drug scaffold.
Oliver L. Symes and James A. Bull
Org. Chem. Front., 2025,12, 6681-6697
From themed collection:
2025 Organic Chemistry Frontiers HOT articles
Abstract
This review examines the mechanism and stereochemical outcome of substitution reactions at chiral S(VI) electrophiles.