In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
A visible-light-driven, photoredox-catalyzed difluoromethylation, SO2 reintegration, and polyfluoroarylation cascade of conjugated dienes has been developed, employing CF2HSO2Na as a bifunctional reagent and polyfluoroarenes as terminating agents.
Three-component reactions enable easy difluorinated-compound synthesis. Advances from 2014–2024 have been categorized as (a) radical, (b) difluorocarbene, (c) nucleophilic or electrophilic fluorine routes.
The review summarises various photo- and electrochemical strategies for trifluoromethylation and fluoroalkylation of different C(sp3)–H, C(sp2)–H, and C(sp)–H bonds in several classes of organic molecules.
Direct functionalization of unactivated alkenes via visible-light photocatalysis has emerged as a highly effective strategy for the rapid construction of multi-functional, complex molecular architectures from simple, abundant chemicals.