Three-component reactions enable easy difluorinated-compound synthesis. Advances from 2014–2024 have been categorized as (a) radical, (b) difluorocarbene, (c) nucleophilic or electrophilic fluorine routes.
NHC and photocatalysis dual-catalyzed mono/difluoromethylative acylation of 1,3-enynes was realized, providing fluormethyl-substituted allenyl ketones. SO2 might play a critical role in achieving high reactivity and selectivity.
This review will focus on the electrochemical synthesis of diversified functionalized oxindole derivatives through C-S, C-O, C-C, C-Se, and C-N bond formation over the past decade.
A new series of 5-(thiophen-2-yl)isoxazoles has been designed, synthesized, and subjected to in vitro anti-cancer screening, which revealed a new molecule, TTI-6, to be the best anti-breast cancer agent (IC50 = 1.91 μM against MCF-7) among others.
A simple and practical visible light-driven photoredox-catalyzed three-component carbotrifluoromethylation of alkenes is revealed for the synthesis of 1,4-bis(trifluoromethylated) compounds.