The synthesis of β-trifluoromethylthiolation enamines and β-trifluoromethylthiolation enamides was realized involving an EDA photochemistry strategy.
Using S-trifluoromethyl thioesters as bifunctional reagents, we developed photoredox/copper dual-catalyzed 1,2-acyl-trifluoromethylthiolation of alkenes and 1,4-acyl-trifluoromethylthiolation of 1,3-enynes.
We reported a direct simple trifluoromethylthiolation reaction of various terminal alkynes using a new hypervalent trifluoromethylthio-iodine(III) reagent TFTI in a fluorinated alcohol, either hexafluoro-2-propanol or perfluoro-tert-butanol.
By using a combination of BiCl3 and TBACl as a ligand-to-metal charge transfer (LMCT) photocatalyst, hydrogen atom transfer trifluoromethylthiolation of aldehydes was achieved under visible light irradiation.
β-Trifluorosulfinylesters, a family of novel reagents from commercially available starting materials for direct trifluoromethylthiolation and trifluoromethylsulfinylation were developed.