This review summarizes the recent advances in the photo-promoted synthesis of polycyclic quinazolinones from unactivated alkene-tethered quinazolinones over the past five years (2021–2025).
A base-promoted atom economical and unexpectedly selective cyclization strategy was developed for the synthesis of indole-fused azepino[2,1-b]quinazolinones and spiroindole-pyrrolo[2,1-b]quinazolinones.
Biologically active [1,5]diazocino[2,1-b]quinazolinones were synthesized via base-promoted [4 + 4] cycloaddition of 2-alkynyl quinazolinones with aza-ortho-quinone methides.
We have provided a comprehensive analysis of the construction of N-containing heterocyclic compounds and their functionalization without the use of external photocatalysts, under UV/visible-light exposure in different conditions.
Synthesis of fifteen 2,N3-disubstituted 4-quinazolinones is achieved in three steps from simple building blocks, facilitated by a regioselective N-alkylation and application of principles from both modular and divergent synthesis.