In this review, we summarize various strategies for constructing CF2H groups based on different approaches, resulting in a series of difluoromethyl derivatives.
A simple and efficient method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent.
Difluorocarbene can function as a versatile fluorine and carbon source, engaging in unique reactions with amines to achieve important transformations, including fluorination. These reactions demonstrate its broad prospects for synthetic applications.
We highlight the most significant advances and developments in the direct C–H difluoromethylation of heteroaromatic compounds reported up to the end of 2025.
We report a new streamlined approach for the difluoromethylation of ubiquitous phenols using inexpensive bromo(difluoro)acetic acid, yielding a wide array of structurally diverse OCF2H-based building blocks in a single step.